An unlikely use for diamonds

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NYC Wholesale Diamonds found this fascinating article on Phys.org today…..Enjoy

Published in Nature Nanotechnology, researchers from Cardiff University have unveiled a new method for viewing nanodiamonds inside human living cells for purposes of biomedical research.

Nanodiamonds are very small particles (a thousand times smaller than human hair) and because of their low toxicity they can be used as a carrier to transport drugs inside cells. They also show huge promise as an alternative to the organic fluorophores usually used by scientists to visualise processes inside cells and tissues.

A major limitation of organic fluorophores is that they have the tendency to degrade and bleach over time under light illumination. This makes it difficult to use them for accurate measurements of cellular processes. Moreover, the bleaching and chemical degradation can often be toxic and significantly perturb or even kill cells.

There is a growing consensus among scientists that nanodiamonds are one of the best inorganic material alternatives for use in biomedical reseach because of their compatibility with human cells, and due to their stable structural and chemical properties.

Previous attempts by other research teams to visualise nanodiamonds under powerful light microscopes have run into the obstacle that the diamond material per se is transparent to visible light. Locating the nanodiamonds under a microscope had relied on tiny defects in the crystal lattice, which fluoresce under light illumination.

Production of the defects proved both costly and difficult to realise in a controlled way. Furthermore, the fluorescence light emitted by these defects, and in turn the image gleaned from the microscopic exploration of these flawed nanodiamonds, is sometimes also unstable.

In their latest paper, researchers from Cardiff University’s Schools of Biosciences and Physics showed that non-fluorescing nanodiamonds (diamonds without defects) can be imaged optically and far more stably via the interaction between the illuminating light and the vibrating chemical bonds in the diamond lattice structure which results in scattered light at a different colour.

The paper describes how two laser beams beating at a specific frequency are used to drive chemical bonds to vibrate in sync. One of these beams is then used to probe this vibration and generate a light, called coherent anti-Stokes Raman scattering (CARS).

By focusing these laser beams onto the nanodiamond, a high-resolution CARS image is generated. Using an in-house built microscope, the research team was able to measure the intensity of the CARS light on a series of single nanodiamonds of different sizes.

The nanodiamond size was accurately measured by means of electron microscopy and other quantitative optical contrast methods developed within the researcher’s lab. In this way, they were able to quantify the relationship between the CARS light intensity and the nanoparticle size.

Consequently, the calibrated CARS signal enabled the team to analyse the size and number of nanodiamonds that had been delivered into living cells, with a level of accuracy hitherto not achieved by other methods.

Professor Paola Borri from the School of Biosciences, who led the study, said: “This new imaging modality opens the exciting prospect of following complex cellular trafficking pathways quantitatively with important applications in drug delivery. The next step for us will be to push the technique to detect nanodiamonds of even smaller sizes than what we have shown so far and to demonstrate a specific application in drug delivery.”

The paper describes how two laser beams beating at a specific frequency are used to drive chemical bonds to vibrate in sync. One of these beams is then used to probe this vibration and generate a light, called coherent anti-Stokes Raman scattering (CARS).

By focusing these laser beams onto the nanodiamond, a high-resolution CARS image is generated. Using an in-house built microscope, the research team was able to measure the intensity of the CARS light on a series of single nanodiamonds of different sizes.

The nanodiamond size was accurately measured by means of electron microscopy and other quantitative optical contrast methods developed within the researcher’s lab. In this way, they were able to quantify the relationship between the CARS intensity and the nanoparticle size.

Consequently, the calibrated CARS signal enabled the team to analyse the size and number of nanodiamonds that had been delivered into living cells, with a level of accuracy hitherto not achieved by other methods.

Professor Paola Borri from the School of Biosciences, who led the study, said: “This new imaging modality opens the exciting prospect of following complex cellular trafficking pathways quantitatively with important applications in . The next step for us will be to push the technique to detect nanodiamonds of even smaller sizes than what we have shown so far and to demonstrate a specific application in drug delivery.”

Read more at: http://phys.org/news/2014-10-diamonds.html#jCp

Keith J. Saxe
Founder/President

NYC Wholesale Diamonds
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Suite 3A
New York City 10036
(212) 719-2214 
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A unique, personal jeweler who works nationwide, Keith Saxe is GIA and FIT trained and has been a trusted high end diamond jewelry specialist for 26 years. He is the founder and
president ​ of NYC Wholesale Diamonds located at 47 West 47th Street Suite 3A in the New York City Diamond District. His website is www.NYCWholesaleDiamonds.com and he authors a blog www.NYCDiamondBlog.com. ​Keith has a full service store located across the street from his private office,​ and ​a San Diego factory showroom. He offers GIA Certified Ideal Cut Diamonds,​ and state of the art fine jewelry designs at low wholesale prices. Keith has been named the N.Y. Diamond District’s Favorite Jeweler by the N.Y. Post’s Savvy Shopper column, had his diamond education articles published, been recommended in the New York Times, CNN reporter Robyn Spizman’s ‘Perfect Present Guide’ and ‘The GIFTionary’, as well as having his Diamond Halo Engagement Ring design featured on ‘The Knot’ http://www.theknot.com/weddings/album/a-preppy-upstate-wedding-in-aurora-ny-144122

 

Published in Nature Nanotechnology, researchers from Cardiff University have unveiled a new method for viewing inside human for purposes of biomedical research.

Nanodiamonds are very small particles (a thousand times smaller than human hair) and because of their low toxicity they can be used as a carrier to transport drugs inside cells. They also show huge promise as an alternative to the organic fluorophores usually used by scientists to visualise processes inside cells and tissues.

Read more at: http://phys.org/news/2014-10-diamonds.html#jCp

Tiny diamonds are providing scientists with new possibilities for accurate measurements of processes inside living cells with potential to improve drug delivery and cancer therapeuticsRead more at: http://phys.org/news/2014-10-diamonds.html#jCp
Tiny diamonds are providing scientists with new possibilities for accurate measurements of processes inside living cells with potential to improve drug delivery and cancer therapeuticsRead more at: http://phys.org/news/2014-10-diamonds.html#jCp

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THE CASE FOR PLATINUM WEDDING BANDS

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Here at NYC Wholesale Diamonds we are thrilled to help our happily engaged couples with our magnificent selection of quality wedding bands. The debate between platinum and white gold is complex, and really depends on many variables. The following is the case for why men should choose Platinum Wedding Bands.

Congratulations to all you soon-to-be grooms. Now that your wedding is only months away, your jewelry collection – just a watch, huh? – is about to increase by as much as 50 percent.

Meaning, it’s time to start thinking about what kind of wedding band you want for yourself.

Wedding bands have become the norm for men in recent years

– 97 percent of grooms in The Knot Market Intelligence’s “2011 Engagement & Jewelry Study” opted for one – so even if you have any doubts, your bride will probably set you straight. That means your only real decision is what kind of band best suits you.

To hear CNNMoney.com tell it, there are basically two camps: those who “don’t want to compromise” when it comes to quality (platinum bands), and those who feel they cannot afford the best and therefore need to settle (bands made from alternative metals). But, as jewelry expert Michael O’Connor points out, that doesn’t really give the whole picture.

“It’s true that platinum is so rare – 30 times more so than gold – that if all the world’s supply were melted and poured into an Olympic-size pool, it would barely reach your ankles,” O’Connor says. “But men’s platinum bands start at $500.”

That turns out to be pretty comparable to the cost of the two most popular alternative metals: titanium and tungsten carbide. Both are perhaps best known for being used to make fighter jets. Cool, right? Well, yes, but that also means they’re intrinsically lightweight and lack the heft of platinum.

“Most men prefer something that feels masculine on their finger,” says O’Connor.

There are other facts to consider, too. Tungsten and titanium jewelry will need special reconditioning if scratched, and cannot be resized. Even the more popular white gold will require rhodium replating to restore its white color due to wear over time. And while platinum – as all precious metals – can scratch, the metal is simply displaced on the surface of the ring, meaning very little metal is lost in wear. That makes it the most durable family heirloom that will last generations.

Still confused? Then ask yourself this question: How committed are you to your future wife?

If the answer’s what we think, then know that platinum has traditionally symbolized a relationship that will endure since it doesn’t fade or change color. “That’s the kicker for a lot of couples,” says O’Connor.

Keith Saxe is GIA and FIT trained and has been a trusted high end diamond jewelry specialist for 26 years. He is the founder and president of NYC Wholesale Diamonds located at 47 West 47th Street Suite 3A in the New York City Diamond District. His website is www.NYCWholesaleDiamonds.com and he authors a blog www.NYCDiamondBlog.com. Keith has a full service store located across the street from his private office, and a San Diego factory showroom. He offers GIA Certified Ideal Cut Diamonds, and state of the art fine jewelry designs at low wholesale prices. Keith has been named the N.Y. Diamond District’s Favorite Jeweler by the N.Y. Post’s Savvy Shopper column, had his diamond education articles published, been recommended in the New York Times, CNN reporter Robyn Spizman’s ‘Perfect Present Guide’ and ‘The GIFTionary’, as well as having his Diamond Halo Engagement Ring design featured on ‘The Knot’ http://www.theknot.com/weddings/album/a-preppy-upstate-wedding-in-aurora-ny-144122

 

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NYC Wholesale Diamonds Announces 2014 Holiday Designs!

Check out our 2014 Holiday Collection at NYC Wholesale Diamonds!

 

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Check out some of our new 2014 engagement rings! 

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Sapphire, The September Birthstone

Sapphire, the September birthstone, has been popular since the Middle Ages and, according to folklore, will protect your loved ones from envy and harm. Continue reading

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Did You Know that NYC Wholesale Diamonds Was Just Highly Recommended by Robyn Spizman?

Did you know that Keith Saxe and NYC Wholesale Diamonds was highly recommended by Robyn Spizman?

Robyn Spizman is a New York Times Bestselling Author, Consumer Advocate and Television Personality. Robyn is often on the Today Show and she is well known as one of the country’s leading authorities on shopping, products and gift-giving. 

We were so excited that we had to tweet about it!

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Rare 3.37-Carat ‘Purple Orchid’ Diamond To Be Unveiled in Hong Kong

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A fancy intense pinkish purple VS2 diamond will be shown to the public for the first time during the September Hong Kong Jewelry & Gem Fair, September 15 – 21. The 3.37-carat gem, named the “Purple Orchid,” has an asking price of $4 million, or nearly $1.2 million per carat.

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